Description

Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 25% of the population above 80 years of age with depositions mainly found in the heart.

Amount

1mg

Format

Lyophilized

Molecular Weight

13760 Da

Sequence

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKV
EIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Purity

95% by Chromatography and SDS-PAGE

Counter Ion

Ammonium Carbonate

Solubility

The lyophilized protein is readily soluble in PBS pH 7.4.

Storage

Store at -20°C upon arrival.

Source

Protein expressed in Escherichia coli.