Lipid Iron Oxide Nanoparticles With Amine ILA is a group of lipid-coated water soluble iron oxide nanoparticles with amine groups on their surfaces. The overall thickness of the organic layers is about 1-2 nm. Their zeta potential is near neutral. The hydrodynamic size established using a Zeta Trac (DLS) is about 3-8 nm larger than the inorganic core size that is measured with TEM. The amine groups can be used in conjugations with different molecules. Lipid-coated nanoparticles have excellent compatibility for in vivo studies because these are prepared with physiological lipids. ILAs show stability and resistance to aggregation in commonly used biocompatible buffers such as borate, Tris, HEPES, PBS and MES buffers, as well as in cell culture medium. ILA is autoclavable.