轉(zhuǎn)錄調(diào)節(jié)因子DEC2抗體
規(guī)格：1mg/1ml
英文名： 42706
別名： SHARP-1; bHLH protein DEC2; bHLHB3; bHLHe41; Class B basic helix loop helix protein 3; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-helix protein 41; DEC2; Differentially express
分子量： 50kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SHARP1/D
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow,
細(xì)胞定位：細(xì)胞核
轉(zhuǎn)錄調(diào)節(jié)因子DEC2抗體產(chǎn)品介紹：background: DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy and Drosophila Enhancer of split m7. DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells. DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1. DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes. Both DEC1 and 轉(zhuǎn)錄調(diào)節(jié)因子DEC2抗體DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion. Brief light impulses induce the expression of DEC1 in a phase-dependent manner. Function: May be a transcriptional repressor that represses both basal and activated transcription. Subunit: Homodimerize. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange轉(zhuǎn)錄調(diào)節(jié)因子DEC2抗體 domain. Gene ID: 79365 Database links: Entrez Gene: 79365 Human Entrez Gene: 79362 Mouse Entrez Gene: 117095 Rat Omim: 606200 Human SwissProt: Q9C0J9 Human SwissProt: Q99PV5 Mouse SwissProt: O35779 Rat Unigene: 177841 Human Unigene: 154529 Mouse Unigene: 10784 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品應(yīng)用轉(zhuǎn)錄調(diào)節(jié)因子DEC2抗體：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 **學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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