鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2/唐氏綜合征候選區(qū)域蛋白1樣蛋白2抗體
規(guī)格：1mg/1ml
英文名： Calcipressin 2
別名： DSCR1L1; Calcipressin 2; Calcipressin-2; CSP2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1 like 1 protein; MCIP2; Myocyte enriched calcineurin interacting protein 2;
分子量： 22kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Calcipre
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
細(xì)胞定位：
鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2/唐氏綜合征候選區(qū)域蛋白1樣蛋白2抗體產(chǎn)品介紹：background: Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2/唐氏綜合征候選區(qū)域蛋白1樣蛋白2抗體 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events. Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Tissue Specificity: Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas. Similarity: Belongs to the RCAN family. Gene ID: 10231 Database links: Entrez Gene: 10231 Human Entrez鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2/唐氏綜合征候選區(qū)域蛋白1樣蛋白2抗體 Gene: 53901 Mouse Entrez Gene: 140666 Rat Omim: 604876 Human SwissProt: Q14206 Human SwissProt: Q9JHG2 Mouse SwissProt: Q8CH27 Rat Unigene: 440168 Human Unigene: 710016 Human Unigene: 251242 Mouse Unigene: 24428 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鈣調(diào)神經(jīng)磷酸酶調(diào)節(jié)蛋白2/唐氏綜合征候選區(qū)域蛋白1樣蛋白2抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：心血管 細(xì)胞生物 染色質(zhì)和核信號 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購買風(fēng)險(xiǎn)，建議您在購買前務(wù)必確認(rèn)供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊會員自行發(fā)布，若信息的真實(shí)性、合法性存在爭議，平臺將會監(jiān)督協(xié)助處理，歡迎舉報(bào)