FK506結(jié)合蛋白38抗體
規(guī)格：1mg/1ml
英文名： FKBP38
別名： 38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa antibody FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding pr
分子量： 46kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FKBP38
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
細胞定位：
FK506結(jié)合蛋白38抗體產(chǎn)品介紹：background: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Tissue specificity: Widely expressed. Highest levels seen in the brain. Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probablyFK506結(jié)合蛋白38抗體 interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Subunit: Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. Subcellular Location: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Tissue Specificity: Widely expressed. Highest levels seen in the brain. Similarity: Contains 1 PPIase FKBP-type domain. FK506結(jié)合蛋白38抗體Contains 3 TPR repeats. Gene ID: 23770 Database links: Entrez Gene: 23770 Human Entrez Gene: 14232 Mouse Entrez Gene: 290652 Rat Omim: 604840 Human SwissProt: Q14318 Human SwissProt: O35465 Mouse SwissProt: Q3B7U9 Rat Unigene: 173464 Human Unigene: 141864 Mouse Unigene: 99789 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FK506結(jié)合蛋白38抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細胞生物 **學(xué) 信號轉(zhuǎn)導(dǎo) 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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