細胞周期及凋亡調(diào)節(jié)蛋白1抗體

規(guī)格：1mg/1ml

英文名： DIS

別名： CARP-1; Carp1; CCAR1; CCAR1_HUMAN; Cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator 1; Cell division cycle and apoptosis regulator protein 1; Death Inducer wi

分子量： 133kDa

儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Polyclonal

亞型：IgG

純化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human DIS/CCAR

交叉反應(yīng)：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,

細胞定位：細胞漿

細胞周期及凋亡調(diào)節(jié)蛋白1抗體產(chǎn)品介紹：background: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. Function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator細胞周期及凋亡調(diào)節(jié)蛋白1抗體 proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. Subunit: Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 (By similarity). Subcellular Location: Cytoplasm,細胞周期及凋亡調(diào)節(jié)蛋白1抗體 perinuclear region. Tissue Specificity: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. Similarity: Contains 1 SAP domain. Gene ID: 55749 Database links: Entrez Gene: 423692 Chicken Entrez Gene: 450498 Chimpanzee Entrez Gene: 767587 Cow Entrez Gene: 479230 Dog Entrez Gene: 55749 Human Entrez Gene: 67500 Mouse Entrez Gene: 361849 Rat Omim: 612569 Human SwissProt: Q8IX12 Human SwissProt: Q8CH18 Mouse SwissProt: D3ZG47 Rat Unigene: 49853 Human Unigene: 196371 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

產(chǎn)細胞周期及凋亡調(diào)節(jié)蛋白1抗體品應(yīng)用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：細胞生物  細胞凋亡  細胞周期蛋白  

儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來源： Rabbit

外觀： Lyophilized or Liquid

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