死亡效應(yīng)結(jié)構(gòu)域蛋白2抗體
規(guī)格：1mg/1ml
英文名： DEDD2
別名： Death effector domain containing 2; DED containing protein FLAME 3; DNA binding death effector domain containing protein 2; FADD like anti apoptotic molecule 3; FLAME 3;
分子量： 36kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DEDD2
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
細(xì)胞定位：細(xì)胞核
死亡效應(yīng)結(jié)構(gòu)域蛋白2抗體產(chǎn)品介紹：background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2. Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3死亡效應(yīng)結(jié)構(gòu)域蛋白2抗體. Subunit: Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD. Subcellular Location: Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli. Tissue Specificity: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two 死亡效應(yīng)結(jié)構(gòu)域蛋白2抗體leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. Similarity: Contains 1 DED (death effector) domain. Gene ID: 162989 Database links: Entrez Gene: 162989 Human Entrez Gene: 67379 Mouse Entrez Gene: 687118 Rat Omim: 606841 Human SwissProt: Q8WXF8 Human SwissProt: Q8QZV0 Mouse Unigene: 515432 Human Unigene: 280594 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)死亡效應(yīng)結(jié)構(gòu)域蛋白2抗體品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 細(xì)胞凋亡
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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