脂肪堆積和肥胖相關(guān)蛋白抗體
規(guī)格：1mg/1ml
英文名： FTO
別名： Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; Fto; FTO_HUMAN; Protein fatso.
分子量： 58kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Protein
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
細胞定位：細胞核
脂肪堆積和肥胖相關(guān)蛋白抗體產(chǎn)品介紹：background: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. Tissue specificity: Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. Function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of脂肪堆積和肥胖相關(guān)蛋白抗體 body size and body fat accumulation. Subunit: Monomer. May also exist as homodimer. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary. DISEASE: Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD) [MIM:612938]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain脂肪堆積和肥胖相關(guān)蛋白抗體 deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years. Similarity: Belongs to the fto family. Database links: UniProtKB/Swiss-Prot: Q9C0B1.3 Important Note: This product as supplied is intended for research 脂肪堆積和肥胖相關(guān)蛋白抗體use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：心血管 細胞生物 **學(xué) 神經(jīng)生物學(xué) 糖尿病 ***病
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
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