凋亡加強結(jié)構(gòu)域蛋白4抗體
規(guī)格：1mg/1ml
英文名： CARD4
別名： CARD 4; CARD4; Caspase recruitment domain 4; Caspase recruitment domain containing protein 4; Caspase recruitment domain family member 4; Caspase recruitment domain protein 4; Caspase recruitment doma
分子量： 108kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CARD4
交叉反應(yīng)：Human, Mouse, Rat,
細胞定位：細胞漿 細胞膜
凋亡加強結(jié)構(gòu)域蛋白4抗體產(chǎn)品介紹：background: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Subunit: Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by 凋亡加強結(jié)構(gòu)域蛋白4抗體CARD-CARD interaction. Interacts with ARHGEF2. Subcellular Location: Cytoplasm. Basolateral cell membrane. Recruited to the basolateral membrane compartment in polarized epithelial cells. Tissue Specificity: Highly expressed in ***** heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon. Similarity: Contains 1 CARD domain凋亡加強結(jié)構(gòu)域蛋白4抗體. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Database links: Entrez Gene: 10392 Human Entrez Gene: 107607 Mouse Entrez Gene: 500133 Rat Omim: 605980 Human SwissProt: Q9Y239 Human SwissProt: Q8BHB0 Mouse Unigene: 405153 Human Unigene: 28498 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)凋亡加強結(jié)構(gòu)域蛋白4抗體品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細胞生物 信號轉(zhuǎn)導(dǎo) 細胞凋亡
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購買風(fēng)險，建議您在購買前務(wù)必確認供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊會員自行發(fā)布，若信息的真實性、合法性存在爭議，平臺將會監(jiān)督協(xié)助處理，歡迎舉報