磷酸化Raf激酶抑制蛋白抗體
規(guī)格：1mg/1ml
英文名： phospho-PBP (Ser153)
別名： PBP (phospho S153); p-PBP (phospho S153); p-RKIP (S153); p-RKIP (Ser153); RKIP (phospho-Ser153); RKIP (phospho-S153); phosphatidylethanolamine-binding protein; PEBP; PBP; Phosphatidylethanolamine-bind
分子量： 21kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反應(yīng)：Human, Mouse, Rat, Pig, Rabbit,
細(xì)胞定位：細(xì)胞漿
磷酸化Raf激酶抑制蛋白抗體產(chǎn)品介紹：background: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor磷酸化Raf激酶抑制蛋白抗體. Subunit: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Subcellular Location: Cytoplasm. Similarity: Belongs to the phosphatidylethanolamine-binding protein family. Database links: Entrez Gene: 5037 Human Entrez Gene: 29542 Rat Omim: 604591 Human SwissProt:磷酸化Raf激酶抑制蛋白抗體 P30086 Human SwissProt: P31044 Rat Unigene: 433863 Human Unigene: 29745 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Raf激酶抑制蛋白(PKIP)屬于磷脂酰乙醇胺結(jié)合蛋白（phosphatidylethanolamine-binding protein, PEBP）家族,廣泛存在于各種不同的生物中,PKIP還參與了對NF-kB信號通路和G蛋白偶聯(lián)受體信號通路的調(diào)控,參與NF-κB信號通路的調(diào)控,參與了對細(xì)胞內(nèi)多種信號轉(zhuǎn)導(dǎo)通路的調(diào)節(jié)作用。RKIP在膜的生物合成、精子發(fā)生、神經(jīng)發(fā)育和細(xì)胞凋亡等生理過程中發(fā)揮重要作用，并參與了老年癡呆癥及糖尿病等的病理過程。有學(xué)者認(rèn)磷酸化Raf激酶抑制蛋白抗體為：RKIP有抑制腫瘤細(xì)胞轉(zhuǎn)移的作用。
產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
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