Noxa蛋白抗體
規(guī)格：1mg/1ml
英文名： Noxa
別名： Adult T cell leukemia derived PMA responsive; APR; APR_HUMAN; Immediate early response protein APR; Immediate-early-response protein APR; Phorbol 12 myristate 13 acetate induced protein 1; Phorbol-12-
分子量： 6kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Noxa
交叉反應：Human, Mouse, Rat, Pig, Horse,
細胞定位：細胞漿 線粒體
Noxa蛋白抗體產品介紹：background: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Noxa蛋白抗體Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Subunit: Interacts with MCL1, BCL2A1 and BAX. Subcellular Location: Noxa蛋白抗體Mitochondrion. Tissue Specificity: Highly expressed in ***** T-cell leukemia cell line. Similarity: Belongs to the PMAIP1 family. Database links: UniProtKB/Swiss-Prot: Q13794.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Noxa蛋白抗體產品應用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：腫瘤 細胞生物 細胞凋亡 線粒體
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
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