KB抑制蛋白激酶Ζ抗體
規(guī)格：1mg/1ml
英文名： IKB zeta
別名： I-kappa-B-zeta; Ikappa B zeta; IkappaBzeta; IkB-zeta; IKBZ; IKBZ_HUMAN; IKBzeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; MAIL protein; Molecule possessing ankyrin repeats induced by
分子量： 78kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IKB zeta
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
細(xì)胞定位：細(xì)胞核
KB抑制蛋白激酶Ζ抗體產(chǎn)品介紹：background: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. Function: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activateKB抑制蛋白激酶Ζ抗體 NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Subunit: Interacts with NFKB1/p50. Interacts with RELA. Subcellular Location: Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2. Tissue Specificity: Expressed at high levels in peripheral blood leukocytes and lung, KB抑制蛋白激酶Ζ抗體at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. Similarity: Contains 7 ANK repeats. Database links: UniProtKB/Swiss-Prot: Q9BYH8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KB抑制蛋白激酶Ζ抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 **學(xué) 細(xì)胞凋亡 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶
儲(chǔ)存條件：
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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