緊密連接蛋白2抗體
規(guī)格：1mg/1ml
英文名： Claudin 2
別名： Claudin-2; Claudin2; CLD2_HUMAN; CLDN 2; CLDN2; OTTHUMP; SP 82; SP82.
分子量： 25kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類(lèi)型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Claudin
交叉反應(yīng)：Human, Mouse, Rat, Chicken,
細(xì)胞定位：細(xì)胞膜
緊密連接蛋白2抗體產(chǎn)品介紹：background: The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin superfamily. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding緊密連接蛋白2抗體 claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Subunit: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Subcellular Location: Cell junction; tight junction. Cell membrane. Similarity: 緊密連接蛋白2抗體Belongs to the claudin family. Database links: Entrez Gene: 404089 Cow Entrez Gene: 9075 Human Entrez Gene: 12738 Mouse Entrez Gene: 300920 Rat Omim: 300520 Human SwissProt: P57739 Human SwissProt: O88552 Mouse Unigene: 522746 Human Unigene: 117068 Mouse Unigene: 93431 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
緊密連接蛋白2抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 **學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子
儲(chǔ)存條件：
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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