DNA修復蛋白Rad23抗體
規(guī)格：1mg/1ml
英文名： Rad23
別名： DNA repair protein RAD23; UV excision repair protein RAD23; RAD23_YEAST; YEL037C; SYGP-ORF29.
分子量： 44kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Saccharomyces
交叉反應：Saccharomyces cerevisiae, YEAST,
細胞定位：細胞核 細胞漿
DNA修復蛋白Rad23抗體產品介紹：background: The RAD23 gene of Saccharomyces cerevisiae is required for excision-repair of UV damaged DNA (1). RAD23 resembles the other DNA repair genes, RAD2, RAD6, RAD7, RAD18, and RAD54, all of which also exhibit increased transcription in response to DNA damage and during meiosis (2). RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function (3). RAD23 bears a ubiquitin-like domain at its amino terminus and this ubiquitin-like domain affects protein function in a nonproteolytic manner (3). Rad23 is a highly conserved protein involved in nucleotide excision repair (NER) that associates with the proteasome via its amino-terminus (4). Its carboxy-terminal ubiquitin-associated domain is evolutionarily conserved from yeast to humans (4). In addition to a DNA修復蛋白Rad23抗體role in DNA repair events in yeast, several lines of evidence indicate that the Rad23 protein may regulate the activity of the 26 S proteasome (5). Function: Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allowDNA修復蛋白Rad23抗體 access by damage-processing enzymes. Subunit: Interacts directly with PNG1. Subcellular Location: Nucleus. Cytoplasm. Similarity: Contains 2 UBA domains. Contains 1 ubiquitin-like domain. Database links: UniProtKB/Swiss-Prot: P32628.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DNA修復蛋白Rad23抗體產品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：細胞生物 **學 染色質和核信號 表觀遺傳學
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
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