FEM1B抗體
規(guī)格：1mg/1ml
英文名： FEM 1B
別名： F1A-alpha; F1AA; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; Fem1 homolog b; FEM1 like death receptor binding protein; FEM1-beta; FEM1B; FEM1B_HUMAN
分子量： 70kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FEM 1B
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
細胞定位：細胞核 細胞漿
FEM1B抗體產(chǎn)品介紹：background: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to theFEM1B抗體 activation of CHEK1. Subunit: Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1. Subcellular Location: Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin. Tissue Specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. Similarity: Belongs to the fem-1 family.FEM1B抗體 Contains 8 ANK repeats. Contains 1 TPR repeat. Gene ID: 10116 Database links: Entrez Gene: 10116 Human Entrez Gene: 14155 Mouse Entrez Gene: 315745 Rat Omim: 613539 Human SwissProt: Q9UK73 Human SwissProt: Q9Z2G0 Mouse SwissProt: P0C6P7 Rat Unigene: 362733 Human Unigene: 24069 Mouse Unigene: 219320 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FEM1B抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細胞生物 細胞凋亡
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購買風(fēng)險，建議您在購買前務(wù)必確認(rèn)供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊會員自行發(fā)布，若信息的真實性、合法性存在爭議，平臺將會監(jiān)督協(xié)助處理，歡迎舉報