內(nèi)皮細(xì)胞分化鞘脂G蛋白偶聯(lián)受體1抗體
規(guī)格：1mg/1ml
英文名： EDG1
別名： CD363; CHEDG1; D1S3362; ECGF1; EDG1; EDG 1; Endothelial differentiation G-protein coupled receptor 1; Endothelial differentiation sphingolipid G protein coupled receptor 1; G protein coupled sphingoli
分子量： 44kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EDG1/CD3
交叉反應(yīng)：Human, Mouse, Rat, Dog, Horse,
細(xì)胞定位：細(xì)胞膜
內(nèi)皮細(xì)胞分化鞘脂G蛋白偶聯(lián)受體1抗體產(chǎn)品介紹：background: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells,內(nèi)皮細(xì)胞分化鞘脂G蛋白偶聯(lián)受體1抗體 fibroblasts, melanocytes, and cells of epithelioid origin. Post-translational modifications: S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 1901 Database links: Entrez Gene: 281135 Cow Entrez Gene: 100050049 Horse Entrez Gene: 1901 Human Entrez Gene: 13609 Mouse Entrez Gene: 29733 Rat Omim: 601974 Human SwissProt: Q5E9P3 Cow SwissProt: P21453 Human SwissProt: 內(nèi)皮細(xì)胞分化鞘脂G蛋白偶聯(lián)受體1抗體O08530 Mouse SwissProt: P48303 Rat Unigene: 154210 Human Unigene: 982 Mouse Unigene: 109455 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 研究發(fā)現(xiàn)，S1P1與VEGF肩并肩相互協(xié)作，從而促進(jìn)血管生長(zhǎng)。VEGF是很多不同****的作用靶標(biāo)。血管新生在很多**是異常的。靶向S1P1和VEGF可能要比只使用VEGF抑制劑更加有效地****；S1P1是一種關(guān)鍵性的血管新生反應(yīng)性基因。研究人員證實(shí)當(dāng)新的血管網(wǎng)絡(luò)形成時(shí)，由此產(chǎn)生的血液流動(dòng)激**管內(nèi)皮細(xì)胞表面上的S1P1，并把信號(hào)傳遞到這些細(xì)胞內(nèi)部從而讓新形成的血管網(wǎng)內(nèi)皮細(xì)胞分化鞘脂G蛋白偶聯(lián)受體1抗體絡(luò)穩(wěn)定化。因此阻斷S1P1可能有助于切斷給癌性腫瘤提供資源的血液供應(yīng)。
產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 細(xì)胞粘附分子 G蛋白偶聯(lián)受體 內(nèi)皮細(xì)胞 細(xì)胞骨架
儲(chǔ)存條件：
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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