G蛋白偶聯(lián)受體ARHGEF18抗體
規(guī)格：1mg/1ml
英文名： ARHGEF18
別名： p114RhoGEF; 114 kDa Rho specific guanine nucleotide exchange factor; ARHGEF 18; ARHGEF18; KIAA0521; MGC15913; p114 Rho GEF; p114-Rho-GEF; Rho specific guanine nucleotide exchange factor p114; Rho-spec
分子量： 131kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ARHGEF18
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
細(xì)胞定位：細(xì)胞漿
G蛋白偶聯(lián)受體ARHGEF18抗體產(chǎn)品介紹：background: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]. Function: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. It may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It also act as a GEF for RAC1, inducing production of reactive G蛋白偶聯(lián)受體ARHGEF18抗體oxygen species (ROS), but does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Subunit: Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2. Subcellular Location: Cytoplasm. Note: Colocalizes with actin stress fibers. Tissue Specificity: Expressed in all tissues tested withG蛋白偶聯(lián)受體ARHGEF18抗體 highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Database links: Entrez Gene: 23370 Human Entrez Gene: 102098 Mouse Entrez Gene: 304193 Rat SwissProt: Q6ZSZ5 Human SwissProt: Q6P9R4 Mouse Unigene: 465761 Human Unigene: 736818 Human Unigene: 170461 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶聯(lián)受體ARHGEF18抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購買風(fēng)險，建議您在購買前務(wù)必確認(rèn)供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊會員自行發(fā)布，若信息的真實性、合法性存在爭議，平臺將會監(jiān)督協(xié)助處理，歡迎舉報