SPOP蛋白抗體
規(guī)格：1mg/1ml
英文名： SPOP
別名： BTBD32; TEF2; SPOP_HUMAN; Speckle-type POZ protein; HIB homolog 1; Roadkill homolog 1.
分子量： 41kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPOP
交叉反應(yīng)：Human, Mouse, Rat,
細(xì)胞定位：細(xì)胞核
SPOP蛋白抗體產(chǎn)品介紹：background: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this doesSPOP蛋白抗體 not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Subunit: Interacts with GLI2 and GLI3. Homodimer and homooligomer. Heterodimer with SPOPL. Each dimer interacts with two CUL3 molecules. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and homodimeric SPOP, or the heterodimer formed by SPOP and SPOPL, plus a target protein, such as H2AFY,SPOP蛋白抗體 PDX1/IPF1, BMI1, BRMS1 and DAXX. Subcellular Location: Nucleus. Nucleus speckle. Tissue Specificity: Widely expressed. Similarity: Belongs to the Tdpoz family. Contains 1 BTB (POZ) domain. Contains 1 MATH domain. Database links: UniProtKB/Swiss-Prot: O43791 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SPOP蛋白抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：發(fā)育生物學(xué)
儲存條件：
來源： Rabbit
外觀： Lyophilized or Liquid
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