FasL抗體
規(guī)格：1mg/1ml
英文名： Fas Ligand
別名： APO1L; Apoptosis (APO 1) antigen ligand 1; Fas-L; Apoptosis antigen ligand 1; APTL; CD178; CD-178; CD 178; CD95L; CD95 ligand; CD95-L; CD95L protein; FAS antigen ligand; Fas L; Fas Ligand; FASL; Fasl;
分子量： 31kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Fas Liga
交叉反應(yīng)：Human, Mouse, Rat, Cow,
FasL抗體細(xì)胞定位：細(xì)胞膜 細(xì)胞外基質(zhì) 分泌型蛋白
產(chǎn)品介紹：background: FasL (CD95L) is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T cell mediated apoptosis and in T cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). May be released as type II membrane protein. Belongs to the tumor necrosis factor family Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Subunit: Homotrimer (Probable). Interacts with ARHGAP9, FasL抗體BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Secreted. Cytoplasmic vesicle lumen. Lysosome lumen. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Post-translational modifications: N-glycosylated. The soluble form derives from the membrane form by proteolytic processing. Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization. Monoubiquitinated. DISEASE: Defects in FASLG are the cause of autoimmune lymphoproliferativeFasL抗體 syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. Similarity: Belongs to the tumor necrosis factor family. Gene ID: 356 Database links: Entrez Gene: 356 Human Entrez Gene: 14103 Mouse Entrez Gene: 25385 Rat Omim: 134638 Human SwissProt: P48023 Human SwissProt: P41047 Mouse SwissProt: P36940 Rat Unigene: 2007 Human Unigene: 3355 Mouse Unigene: 9725 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Fas-L 是一個與TNFRSF6/FAS 結(jié)合的細(xì)胞因子，一個轉(zhuǎn)導(dǎo)凋亡信號到細(xì)胞內(nèi)的一個受體。他可能參與T-細(xì)胞調(diào)節(jié)凋亡細(xì)胞毒性和T-細(xì)胞的發(fā)育。調(diào)節(jié)凋亡的TNFRSF6/FAS 在外周組織耐受性方面和抗原刺激成熟**細(xì)胞**中起作用。FasL誘導(dǎo)物受體TNFRSF6B/DcR3結(jié)合調(diào)節(jié)其作用。 FasL只表達(dá)于活化的**細(xì)胞，但在小鼠睪丸中可見高表達(dá)的FasL;分子量為36-43kDa。屬于TNF家族。
FasL抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 細(xì)胞生物 **學(xué) 細(xì)胞凋亡
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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