富含脯氨酸突觸相關蛋白SHANK1抗體
規(guī)格：1mg/1ml
英文名： SHANK 1
別名： GKAP/SAPAP interacting protein; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SHANK 1; Somatostatin receptor interacting protein; Somatostatin receptor-
分子量： 225kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Shank1
交叉反應：Human, Mouse, Rat,
富含脯氨酸突觸相關蛋白SHANK1抗體細胞定位：
產(chǎn)品介紹：background: The mechanisms underlying the molecular assemblage of molecules at the synapse are not well understood. Recently, a number of novel anchoring/scaffold proteins that are associated with postsynaptic density (PSD) proteins have been isolated. SHANK1, SHANK2 and SHANK3 constitute a family of proteins that may function as molecular scaffolds in the PSD. SHANK is made of five domain/regions that are probably involved in protein-protein interactions: ankyrin repeats, an SH3 domain, a PDZ domain, a SAM domain, and a proline rich region. SHANK interacts directly with GKAP or SAPAP via its PDZ domain, thus potentially bridging the N-methyl-D-aspartate receptor (NMDA)-PSD-95-GKAP complex. 富含脯氨酸突觸相關蛋白SHANK1抗體Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Subunit: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2. Subcellular Location: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2. Tissue Specificity: Expressed in brain particularly in the amygdala, hippocampus, 富含脯氨酸突觸相關蛋白SHANK1抗體substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously. Similarity: Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain. Gene ID: 50944 Database links: Entrez Gene: 50944 Human Entrez Gene: 243961 Mouse Entrez Gene: 78957 Rat Omim: 604999 Human SwissProt: Q9Y566 Human SwissProt: D3YZU1 Mouse SwissProt: Q9WV48 Rat Unigene: 274255 Human Unigene: 360368 Mouse Unigene: 225968 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 有學者認為：shank-1似乎是具有興奮性突觸PSD中的連接蛋白，它可以連接后突觸膜受體，包括NMDA-Type和谷氨酸受體等。在樹突旋轉和突觸連接的有機體功能和結構方面起重要作用。shank1 主要表達在腦組織內，屬于shank家族。
富含脯氨酸突觸相關蛋白SHANK1抗體產(chǎn)品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：神經(jīng)生物學 信號轉導
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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