GDNF家族受體α-1抗體
規(guī)格：1mg/1ml
英文名： GDNFRA
別名： GDNF Receptor alpha 1; GFRa-1; GFR alpha; GDNFR alpha; TmR1; GFR alpha-1; RETL1; RET ligand 1; TGF-beta related neurotrophic factor receptor-1; AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ315
分子量： 44kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GFR Alph
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
GDNF家族受體α-1抗體細(xì)胞定位：細(xì)胞膜
產(chǎn)品介紹：background: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of tGDNF家族受體α-1抗體he RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq] Function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Subunit: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Similarity: Belongs to the GDNFR family. Gene ID: 2674 Database links: Entrez Gene: 2674 Human Entrez Gene: 14585 Mouse Entrez Gene: 25454 Rat Omim: 601496 Human SwissProt: P56159 Human SwissProt: GDNF家族受體α-1抗體P97785 Mouse SwissProt: Q62997 Rat Unigene: 591913 Human Unigene: 88489 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GFRα-1是由68個(gè)氨基酸組成的蛋白，廣泛表達(dá)于**神經(jīng)系統(tǒng)和外周器官。活性亞單位由兩個(gè)GFRα-1分子中間由二硫鍵連接而成的復(fù)合物。屬于GDNFR 家族成員。
GDNF家族受體α-1抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：**學(xué) 神經(jīng)生物學(xué)
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
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