腺苷酸環(huán)化酶激活肽受體-II/血管活性腸肽受體-II抗體
規(guī)格：1mg/1ml
英文名： VPAC2R
別名： VIP receptor II; VIP receptor2; VIP receptor-2; PACAP type-3; VIP type-2 receptor; Vipr2; Vip2; VPAC2; VPAC2R; Vasoactive intestinal polypeptide receptor 2; VIP-R-2; Pituitary adenylate cyclase-activa
分子量： 48kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from rat VIP recept
交叉反應(yīng)：Human, Mouse, Rat, Rabbit,
腺苷酸環(huán)化酶激活肽受體-II/血管活性腸肽受體-II抗體細(xì)胞定位：細(xì)胞膜
產(chǎn)品介紹：background: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/ secretin family. It is widely distributed in the body, and a variety of biological actions have been reported. Recent studies have shown that there is a family of PACAP receptors (PACAPRs), and two members of this family have been identified. Mouse PACAPR-3 is a protein of 437 amino acids that has 50% and 51% identity with rat PACAP type I and type II receptors, respectively. It binds to vasoactive intestinal polypeptide as well as PACAP-38 and -27, with a slightly higher affinity for PACAP-38, PACAPR-3 mRNA is expressed at high levels in MIN6, 腺苷酸環(huán)化酶激活肽受體-II/血管活性腸肽受體-II抗體at moderate levels in pancreatic islets and other insulin-secreting cell lines, HIT-T15 and RINm5F, as well as in the lung, brain, stomach, and colon, and at low levels in the heart. PACAPR-3 participates in the regulation of insulin secretion. insulin secretion from MIN6 cells is significantly stimulated by PACAP-38. Function: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, PEER, MOLT-4, HSB, 腺苷酸環(huán)化酶激活肽受體-II/血管活性腸肽受體-II抗體YT and Tsup-1, but not in the T-cell lines HARRIS and HUT 78. Similarity: Belongs to the G-protein coupled receptor 2 family. Gene ID: 7434 Database links: Entrez Gene: 7434 Human Omim: 601970 Human SwissProt: P41587 Human Unigene: 585052 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PACAP 受體分為兩個(gè)亞型，PACAP-2型受體對(duì)PACAP是特異性的，與PACAP的親和力比VIP高100-1000倍，PACAP-II型受體與PACAP和VIP的親和力相似，對(duì)二者無選擇性。此抗體即為后者。
腺苷酸環(huán)化酶激活肽受體-II/血管活性腸肽受體-II抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 **學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長因子和** 細(xì)胞膜受體 G蛋白偶聯(lián)受體
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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