胰島素受體底物-4抗體
規(guī)格：1mg/1ml
英文名： IRS-4
別名： IRS4; 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS 4; PY160; IRS4_MOUSE; IRS-4; Phosphoprotein of 160 kDa; pp160.
分子量： 134kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse IRS-4
交叉反應(yīng)：Mouse, Rat,
胰島素受體底物-4抗體細(xì)胞定位：細(xì)胞漿 細(xì)胞膜
產(chǎn)品介紹：background: IRS4 (Insulin receptor substrate 4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signaling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. Function: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in胰島素受體底物-4抗體 the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2. Subunit: Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH. Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2. Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in skeletal muscle, brain, heart, kidney and liver. Post-translational modifications: Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on 胰島素受體底物-4抗體Tyr-894 in response to FGF2 signaling. Phosphorylation of Tyr-894 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction. Similarity: Contains 1 IRS-type PTB domain. Contains 1 PH domain. Gene ID: 16370 Database links: Entrez Gene: 8471 Human Entrez Gene: 16370 Mouse Entrez Gene: 315350 Rat Omim: 603510 Human SwissProt: O14654 Human Unigene: 460872 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰島素受體底物-4屬于IRS家族。IRS作為insulin/IGF 信號途徑的核心介子對細(xì)胞的生長、發(fā)育及新陳代謝的調(diào)節(jié)起關(guān)鍵作用。
胰島素受體底物-4抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：信號轉(zhuǎn)導(dǎo)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購買風(fēng)險(xiǎn)，建議您在購買前務(wù)必確認(rèn)供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊會(huì)員自行發(fā)布，若信息的真實(shí)性、合法性存在爭議，平臺將會(huì)監(jiān)督協(xié)助處理，歡迎舉報(bào)