GDNF家族受體α4抗體
規(guī)格：1mg/1ml
英文名： GFRA4
別名： Persephin receptor; GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell lin
分子量： 27kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GFRA4
交叉反應(yīng)：Human, Mouse, Rat,
GDNF家族受體α4抗體細胞定位：
產(chǎn)品介紹：background: The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. Subcellular Location: Isoform GFRalpha4a: Cell membrane; Lipid-anchor, GDNF家族受體α4抗體GPI-anchor. Isoform GFRalpha4b: Cell membrane; Lipid-anchor, GPI-anchor. Isoform GFRalpha4c: Secreted. Tissue Specificity: Predominantly expressed in the ***** thyroid gland. Low levels also found in fetal adrenal and thyroid glands.GDNF家族受體α4抗體 Similarity: Belongs to the GDNFR family. Gene ID: 64096 Database links: Entrez Gene: 64096 Human SwissProt: Q9GZZ7 Human Unigene: 302025 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Persephin receptor 是一個新的神經(jīng)營養(yǎng)因子，屬于GDNFR家族，調(diào)節(jié)GDNF誘導(dǎo)的自動磷酸化和RET受體的活性。他在維持神經(jīng)系統(tǒng)正常生存中起重要作用。主要表達在正常和惡性甲狀腺髓細胞。分子量約為30kDa。
GDNF家族受體α4抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：神經(jīng)生物學(xué) 通道蛋白
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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