神經(jīng)激肽B受體抗體

規(guī)格：1mg/1ml

英文名： Neurokin B receptor

別名： NMBR; NKR; Neuromedin K receptor; NK-4 receptor; NKR; Neurokinin B receptor; NK-4R; K1R; Neurokinin 4 R; NK-3R; Tachykinin receptor 3; MGC148060; MGC148061; NK 3 receptor; NK3 receptor; NK3R; TAC 3R;

分子量： 52kDa

儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Polyclonal

亞型：IgG

純化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human NKR

交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,

神經(jīng)激肽B受體抗體細(xì)胞定位：細(xì)胞膜

產(chǎn)品介紹：background: The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms 神經(jīng)激肽B受體抗體(e.g. G-protein coupled activation of phospholipase C). Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. DISEASE: Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably 神經(jīng)激肽B受體抗體results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 6870 Database links: Entrez Gene: 6870 Human Entrez Gene: 404136 Cow Entrez Gene: 403814 Dog Entrez Gene: 21338 Mouse Entrez Gene: 100008721 Rabbit Entrez Gene: 24808 Rat Omim: 162332 Human SwissProt: P29371 Human SwissProt: P47937 Mouse SwissProt: O97512 Rabbit SwissProt: P16177 Rat Unigene: 942 Human Unigene: 103810 Mouse Unigene: 9702 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)激肽B受體抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞膜受體  G蛋白信號  

儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來源： Rabbit

外觀： Lyophilized or Liquid

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