半胱胺酸蛋白酶蛋白-6抗體
規(guī)格：1mg/1ml
英文名： Caspase-6 (CT)
別名： Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related
分子量： 11kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Caspase-
交叉反應(yīng)：Human, Mouse, Rat,
半胱胺酸蛋白酶蛋白-6抗體細(xì)胞定位：
產(chǎn)品介紹：background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.半胱胺酸蛋白酶蛋白-6抗體 This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Subcellular Location: Cytoplasm. Post-translational modifications: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. Similarity: Belongs to the peptidase C14A family. Gene ID: 839 Database links: Entrez Gene: 839半胱胺酸蛋白酶蛋白-6抗體 Human Entrez Gene: 12368 Mouse Entrez Gene: 83584 Rat Omim: 601532 Human SwissProt: P55212 Human SwissProt: O08738 Mouse SwissProt: O35397 Rat Unigene: 654616 Human Unigene: 281379 Mouse Unigene: 88160 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Caspase-6 與Caspase-3有38%的同源性，屬胱氨酸-天冬氨酸蛋白酶家族。在凋亡執(zhí)行階段起中心作用，可被Caspase-7、-8、-10剪切。它是**一個(gè)可以剪切核纖層蛋白的Caspase。
半胱胺酸蛋白酶蛋白-6抗體產(chǎn)品應(yīng)用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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