軸索過(guò)度生長(zhǎng)抑制因子-A抗體
規(guī)格：1mg/1ml
英文名： Nogo-A
別名： Nogo A; reticulon-4 isoform D; ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; Neurite growth inhibitor 220; Neurite Outgrowth Inhibitor; Neuroendocrine specific protein; Neur
分子量： 131kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類(lèi)型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse RTN4 pro
交叉反應(yīng)：Mouse, Rat,
軸索過(guò)度生長(zhǎng)抑制因子-A抗體細(xì)胞定位：細(xì)胞漿 細(xì)胞膜
產(chǎn)品介紹：background: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system.軸索過(guò)度生長(zhǎng)抑制因子-A抗體 Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the ***** CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1. Subcellular Location: Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. 軸索過(guò)度生長(zhǎng)抑制因子-A抗體Tissue Specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific. Similarity: Contains 1 reticulon domain. Gene ID: 68585 Database links: Entrez Gene: 57142 Human Entrez Gene: 68585 Mouse Entrez Gene: 83765 Rat Omim: 604475 Human SwissProt: Q9NQC3 Human SwissProt: Q99P72 Mouse SwissProt: Q9JK11 Rat Unigene: 704007 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） Nogo-A軸索生長(zhǎng)抑制因子在**神經(jīng)的髓鞘上表達(dá)并在抑制損傷軸索修復(fù)中起著關(guān)鍵作用，從而有限制神經(jīng)功能恢復(fù)的現(xiàn)象。主要定位細(xì)胞核。
軸索過(guò)度生長(zhǎng)抑制因子-A抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 神經(jīng)生物學(xué)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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