芳香化酶/細(xì)胞色素P450/雌**合成酶抗體

規(guī)格：1mg/1ml

英文名： Aromatase

別名： Cytochrome p450 19A1; Estrogen synthetase; ARO 1; ARO; ARO1; CPV; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; MGC104309; P 450AROM; P450AROM; CP19A_HUMAN; Cytoch

分子量： 55kDa

儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Polyclonal

亞型：IgG

純化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human Aromatas

交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

芳香化酶/細(xì)胞色素P450/雌**合成酶抗體細(xì)胞定位：細(xì)胞膜

產(chǎn)品介紹：background: Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function. Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Subcellular Location: Membrane; Peripheral membrane protein. Tissue Specificity: Brain, placenta and gonads. DISEASE: Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity. Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:613546].芳香化酶/細(xì)胞色素P450/雌**合成酶抗體 AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In ***** females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries. Similarity: Belongs to the cytochrome P450 family. Gene ID: 1588 Database links: Entrez Gene: 1588 Human Entrez Gene: 13075 Mouse Entrez Gene: 25147 Rat Omim: 107910 Human SwissProt: P11511 Human SwissProt: P28649 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 芳香化酶是一種微粒體酶系統(tǒng)，催化睪酮經(jīng)三步連續(xù)強(qiáng)化轉(zhuǎn)變成17-β-雌二醇,在反應(yīng)中睪酮作為**原。 細(xì)胞色素P450主要分布在內(nèi)質(zhì)網(wǎng)和線粒體內(nèi)膜上，作為一種末端加氧酶，參與了生物體內(nèi)的甾醇類**合成等過(guò)程。 近年來(lái)，對(duì)細(xì)胞色素P450的結(jié)構(gòu)、功能特別是對(duì)其在**代謝中的作用的研究有了較大的進(jìn)展。 *新研究表明細(xì)胞色素P450還是**代謝過(guò)程中的關(guān)鍵酶，而且對(duì)細(xì)胞因子和體溫調(diào)節(jié)都有重要影響。 芳香化酶-細(xì)胞色素P450作為和**代謝及細(xì)胞因子相關(guān)的重要酶類，芳香化酶/細(xì)胞色素P450/雌**合成酶抗體在**代謝和**中起著相當(dāng)重要的作用，對(duì)于它的研究將有助于新藥的開(kāi)發(fā)，并能幫助人們更加清楚的認(rèn)識(shí)**的代謝途徑，在未來(lái)的新藥中減少副作用，增加**療效。隨著對(duì)細(xì)胞色素P450研究的深入，將有更多相關(guān)的**代謝途徑被發(fā)現(xiàn)，人們開(kāi)發(fā)新藥的視野將更加開(kāi)闊，新藥開(kāi)發(fā)的速度也將加快，質(zhì)量進(jìn)一步提高。 鑒于P450的研究無(wú)論在理論上探索生物的生理代謝、選擇進(jìn)化和生物與環(huán)境的關(guān)系方面,或在環(huán)境保護(hù)、農(nóng)業(yè)生態(tài)、生物防治、作物基因工程和醫(yī)藥衛(wèi)生等應(yīng)用方面,都有廣泛的實(shí)踐意義,因此,應(yīng)該受到更大的關(guān)注和重視。

芳香化酶/細(xì)胞色素P450/雌**合成酶抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：神經(jīng)生物學(xué)  細(xì)胞凋亡  合成與降解  

儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來(lái)源： Rabbit

外觀： Lyophilized or Liquid

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