瘦素受體抗體
規(guī)格：1mg/1ml
英文名： Leptin receptor
別名： obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fatty; Leptin receptor gene related protein; Leptin receptor precursor; OB R; OB-R; OB R gene related protein; O
分子量： 126kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Leptin r
交叉反應：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
瘦素受體抗體細胞定位：細胞膜 分泌型蛋白
產(chǎn)品介紹：background: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] Function: Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway Subunit: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits LRb signaling.瘦素受體抗體 Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable). Tissue Specificity: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In *****s highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus. Post-translational modifications: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like (immunoglobulin-like) domain. Gene ID: 3953 Database links: Entrez Gene: 3953 Human Entrez Gene: 16847 Mouse Entrez Gene: 24536 Rat Omim: 601007 Human SwissProt: P48357 Human SwissProt: P48356 Mouse SwissProt:瘦素受體抗體 Q62959 Rat Unigene: 23581 Human Unigene: 723178 Human Unigene: 259282 Mouse Unigene: 9891 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Leptin是一種分子量為16kDa的脂肪組織源**，由脂肪細胞分泌的，具有強親水性，以單體形式存在于血漿中。 Leptin 具有廣泛的生物學效應，作用于下丘腦，調節(jié)食欲、能量代謝及體重。Leptin 還可能作為脂肪-胰島***軸一部分，參與胰島素分泌的調節(jié)。 Leptin receptor (OB-R)是與gp130*密切相關的信號轉導的共同成分,屬1類細胞因子超家族，下丘腦有豐富的Leptin receptor，在其它部位也有分布，但水平較低：如胰島素B細胞；脈絡叢；肝、肺、心、腎、睪丸、**細胞和脂肪細胞中。人類存在四個異性體，均為單跨膜受體。其中OB-Rb在胞內結構域*長，是**能進行信號傳導并調節(jié)熱量攝入和能量消耗的異性體。
瘦素受體抗體產(chǎn)品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：心血管 信號轉導 生長因子和**
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Mouse
外觀： Lyophilized or Liquid
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