腫瘤壞死因子β抗體
規(guī)格：1mg/1ml
英文名： TNF beta
別名： TNF-beta; TNF beta; LTalpha; Coley’s toxin; DIF; Differentiation inducing factor; Hemorrhagic factor; LT alpha; LT; LTA; LTalpha; Lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Natu
分子量： 18kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNF beta
交叉反應(yīng)：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
腫瘤壞死因子β抗體細(xì)胞定位：細(xì)胞膜 分泌型蛋白
產(chǎn)品介紹：background: Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Gene Symbol: TNF-Beta; tumor necrosis factor-Beta; Tumor necrosis factor ligand superfamily member 1; TNFSF1; LTA; Lymphotoxin-alpha; TNF-beta; LT-alpha. Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Subunit: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or 腫瘤壞死因子β抗體(less prevalent) two LTA and one LTB subunits. Subcellular Location: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. DISEASE: Genetic variations in LTA are associated with susceptibility to leprosy type 4 (LPRS4) [MIM:610988]; also known as susceptibility to age-dependent leprosy. Leprosy is a chronic infectious disease of peripheral sensory nerves caused by Mycobacterium leprae. Genetic variations in LTA are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. Similarity: Belongs to the tumor necrosis factor family. Gene ID: 4049 Database links: Entrez Gene:腫瘤壞死因子β抗體 4049 Human Entrez Gene: 16992 Mouse Entrez Gene: 25008 Rat Omim: 153440 Human SwissProt: P01374 Human SwissProt: P09225 Mouse SwissProt: Q06332 Rat Unigene: 36 Human Unigene: 87787 Mouse Unigene: 160577 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生長(zhǎng)因子和** 腫瘤壞死因子-β（TNF β）是多功能細(xì)胞因子，又稱****(Lymphotoxin,LT)是由活化**細(xì)胞所產(chǎn)生，它具有抗腫瘤、抗病毒、誘導(dǎo)成纖維細(xì)胞、B細(xì)胞和胸腺細(xì)胞的增殖、分化以及調(diào)節(jié)**功能等廣泛的生物學(xué)效應(yīng)。
腫瘤壞死因子β抗體產(chǎn)品應(yīng)用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 細(xì)胞生物 **學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和**
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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