CD20抗體

規(guī)格：1mg/1ml

英文名： CD20

別名： B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; CD20; CD20_HUMAN.

分子量： 33kDa

儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Polyclonal

亞型：IgG

純化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human CD20

交叉反應(yīng)：Human, Mouse, Rat, Dog, Cow, Rabbit,

CD20抗體細(xì)胞定位：細(xì)胞膜

產(chǎn)品介紹：background: CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit. Function: This protein may be involved in the regulation of B-cell activation and proliferation Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed on B-cells. Post-translational modifications: Phosphorylated. Might be functionally regulated by protein kinase(s). DISEASE: Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; CD20抗體also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Similarity: Belongs to the MS4A family. Gene ID: 931 Database links: Entrez Gene: 931 Human Omim: 112210 Human SwissProt: P11836 Human Unigene: 712553 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. [PHARMACEUTICAL] Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera),CD20抗體 Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity. B**細(xì)胞標(biāo)志物 CD20是B細(xì)胞特異性抗原，其表達(dá)呈細(xì)胞類型一種質(zhì)膜蛋白質(zhì)，參與信號傳導(dǎo)作用，此抗體識別大多數(shù)B細(xì)胞上的一種抗原。多用于標(biāo)記B**細(xì)胞及B細(xì)胞**瘤。 CD20一般不與T細(xì)胞交叉反應(yīng)，對B細(xì)胞**瘤和急慢性**細(xì)胞白血病等有較好的細(xì)胞特異性，因此在惡性**瘤，尤其是T或B細(xì)胞**瘤的分類上，CD20是*常用的B細(xì)胞標(biāo)志。

CD20抗體產(chǎn)品應(yīng)用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：腫瘤  **學(xué)  干細(xì)胞  細(xì)胞表面分子  細(xì)胞類型標(biāo)志物  **細(xì)胞  b-**細(xì)胞  

儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來源： Rabbit

外觀： Lyophilized or Liquid

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