Caspase 激活的脫氧核糖核酸酶抗體
規(guī)格：1mg/1ml
英文名： DFFB
別名： 5730477D02Rik; CAD; Caldesmon; Caspase activated deoxyribonuclease; Caspase activated DNase; Caspase activated nuclease; Caspase-activated deoxyribonuclease; Caspase-activated DNase; Caspase-activated
分子量： 40kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse DFF-40 b
交叉反應(yīng)：Mouse, Rat, Rabbit, Guinea Pig,
Caspase 激活的脫氧核糖核酸酶抗體細(xì)胞定位：細(xì)胞核 細(xì)胞漿
產(chǎn)品介紹：background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments ofCaspase 激活的脫氧核糖核酸酶抗體 DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008]. Function: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. Subunit: Heterodimer of DFFA and DFFB Subcellular Location: Cytoplasm. Nucleus. Similarity: Contains 1 CIDE-N domain. Gene ID: 13368 Database links: Entrez Gene: 1677 Human Entrez Gene: Caspase 激活的脫氧核糖核酸酶抗體13368 Mouse Entrez Gene: 84359 Rat Omim: 601883 Human SwissProt: O76075 Human SwissProt: O54788 Mouse SwissProt: Q99N34 Rat Unigene: 133089 Human Unigene: 388918 Mouse Unigene: 67077 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Caspase 激活的脫氧核糖核酸酶抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 染色質(zhì)和核信號(hào) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Rabbit
外觀： Lyophilized or Liquid
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