酪氨酸羥化酶抗體
規(guī)格：1mg/1ml
英文名： Tyrosine Hydroxylase
別名： Tyrosine Hydroxylase; DYT14; DYT5b; ple; Protein Pale; c; The; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyk2; TY3H_HUMAN; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH.
分子量： 60kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TH
交叉反應(yīng)：Human, Mouse, Rat, Dog, Cow,
酪氨酸羥化酶抗體細(xì)胞定位：
產(chǎn)品介紹：background: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] Function: Plays an important role in the physiology of adrenergic neurons. Tissue Specificity: Mainly expressed in the brain and adrenal glands. DISEASE: Defects in TH are the cause of Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407]. A form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions,酪氨酸羥化酶抗體 often leading to abnormal postures. Some cases present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA. Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls. Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Gene ID: 7054 Database links: Entrez Gene:酪氨酸羥化酶抗體7054 Human Entrez Gene: 21823 Mouse Entrez Gene: 25085 Rat Omim: 191290 Human SwissProt: P07101 Human SwissProt: P24529 Mouse SwissProt: P04177 Rat Unigene: 435609 Human Unigene: 1292 Mouse Unigene: 11082 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)細(xì)胞標(biāo)志物 酪氨酸羥化酶（TH）是兒茶酚胺類神經(jīng)遞質(zhì)即多巴胺、去甲腎上腺素、腎上腺素生物合成過程所需的限速酶，它以四氫生物喋呤啶(BH4)為輔酶，催化酪氨酸的羥化而生成多巴(DOPA)。 已知在患帕金森病(Parkinson disease,PD)時，腦內(nèi)多巴胺(dopamine,DA)的減少與此酶活性低下有關(guān)。因此對PD模型動物來說，若將TH基因植入腦內(nèi)，便可以提高腦內(nèi)DA水平而達(dá)到基因**目的。
酪氨酸羥化酶抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-200 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 **學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 新陳代謝
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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