細(xì)胞色素C抗體

規(guī)格：1mg/1ml

英文名： Cytochrome C

別名： CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome c; MSA06; THC4.

分子量： 12.8/26kDa

儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆類型：Polyclonal

亞型：IgG

純化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human Cytochro

交叉反應(yīng)：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Guinea Pig,

細(xì)胞色素C抗體細(xì)胞定位：細(xì)胞漿 細(xì)胞膜 線粒體

產(chǎn)品介紹：background: Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in the process of oxidative phosphorylation and production of cellular ATP. An increasing amount of interest has been directed toward the role which cytocrome C has been demonstrated to play in apoptotic processes. Following exposure to apoptotic stimuli, cytochrome C is rapidly released from the mitochondria into the cytosol, an event which may be required for the completion of apoptosis in some systems. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis. Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial 細(xì)胞色素C抗體membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Subcellular Location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane. Post-translational modifications: Binds 1 heme group per subunit. Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration. DISEASE: Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively 細(xì)胞色素C抗體few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation. Similarity: Belongs to the cytochrome c family. Gene ID: 54205 Database links: Entrez Gene: 54205 Human Entrez Gene: 13063 Mouse Entrez Gene: 25309 Rat Omim: 123970 Human SwissProt: P99999 Human SwissProt: P62897 Mouse SwissProt: P62898 Rat Unigene: 437060 Human UniProtKB/Swiss-Prot: P99999.2   Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細(xì)胞色素C（cytC）是一種電子傳遞鏈蛋白為線粒體呼吸鏈必須的成份之一。在哺乳動(dòng)物細(xì)胞中，如此高度保守性蛋白常分布在線立體內(nèi)膜。 新近研究證明細(xì)胞漿中細(xì)胞色素C為激活細(xì)胞調(diào)亡所必需的因子。在調(diào)亡的過(guò)程中，細(xì)胞色素C從線立體膜被易位到細(xì)胞漿，由細(xì)胞色素C激活Caspase-3（CPP32）。 細(xì)胞色素C的易位可被過(guò)量表達(dá)的Bcl-2阻斷。細(xì)胞色素B與細(xì)胞色素C1和Rieske蛋白相結(jié)合而形成復(fù)合物III（也稱細(xì)胞色素B-C1復(fù)合物）參與細(xì)胞呼吸鏈。該蛋白動(dòng)物種屬間同源性較高；如 ：豬、犬、牛、雞、豚鼠等。

細(xì)胞色素C抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-200 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究領(lǐng)域：腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  脂蛋白  線粒體  

儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

來(lái)源： Rabbit

外觀： Lyophilized or Liquid

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