腎上腺髓質素抗體
規(guī)格：1mg/1ml
英文名： ADM
別名： Adrenomedullin; ADM; ADM precursor; ADML_HUMAN.
分子量： 20kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADM N-te
交叉反應：Human, Mouse, Rat, Dog, Cow, Horse,
腎上腺髓質素抗體細胞定位：分泌型蛋白
產(chǎn)品介紹：background: Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of4 exons and 3 introns,腎上腺髓質素抗體 with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. 腎上腺髓質素抗體Subcellular Location: Secreted. Tissue Specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. Similarity: Belongs to the adrenomedullin family. Gene ID: 133 Database links: Entrez Gene: 133 Human NCBI: NP_001115 Human Omim: 103275 Human SwissProt: P35318 Human Unigene: 441047 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 腎上腺髓質素（Adrenomedullin， AM）是廣泛分布在腎上腺髓質、肺、心、肝、腎等器官。
腎上腺髓質素抗體產(chǎn)品應用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：腫瘤 心血管 神經(jīng)生物學 信號轉導 細胞凋亡 生長因子和**
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
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