小鼠抗血管內(nèi)皮生長(zhǎng)因子A抗體
規(guī)格：1mg/1ml
英文名： VEGF-A
別名： Vascuoar endothelial growth factor A; vascular endothelial growth factor A isoform 2 precursor; Vegf; VEGF164; VEGFA; MGC70609; MVCD1; VEGF; VPF.
分子量： 24kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Monoclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VEGF-A
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, Guinea Pig,
小鼠抗血管內(nèi)皮生長(zhǎng)因子A抗體細(xì)胞定位：分泌型蛋白
產(chǎn)品介紹：background: This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also, alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants, give rise to additional isoforms. [provided by RefSeq]. Function: Entrez Gene: 7422 Human Entrez Gene: 22339 Mouse Entrez Gene: 83785 Rat Omim: 192240 Human SwissProt: P15692 Human SwissProt: Q00731 Mouse SwissProt: P16612 Rat Unigene: 73793 Human Unigene: 282184 Mouse Unigene: 1923 Rat Subunit: Homodimer; 小鼠抗血管內(nèi)皮生長(zhǎng)因子A抗體disulfide-linked. Also found as heterodimer with PGF Subcellular Location: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. Tissue Specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. DISEASE: Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy小鼠抗血管內(nèi)皮生長(zhǎng)因子A抗體 remains the major cause of new-onset blindness among diabetic *****s. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Similarity: Belongs to the PDGF/VEGF growth factor family. Gene ID: 7422 Database links: Entrez Gene: 7422 Human Entrez Gene: 22339 Mouse Entrez Gene: 83785 Rat Omim: 192240 Human SwissProt: P15692 Human SwissProt: Q00731 Mouse SwissProt: P16612 Rat Unigene: 73793 Human Unigene: 282184 Mouse Unigene: 1923 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
小鼠抗血管內(nèi)皮生長(zhǎng)因子A抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 **學(xué) 生長(zhǎng)因子和** 血管內(nèi)皮細(xì)胞
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Mouse
外觀： Lyophilized or Liquid
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