畸胎瘤衍化生長因子單克隆抗體
規(guī)格：1mg/1ml
英文名： CRIPTO
別名： CRIPTO; CRIPT; CR; CRGF; Cripto 1; Cripto-1; Cripto 1 growth factor; Cripto-1 growth factor; Cripto1; Cripto1 growth factor; Epidermal growth factor like cripto protein CR1; Epidermal growth factor-li
分子量： 13kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Monoclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Teratoca
交叉反應：Human, Mouse, Rat,
畸胎瘤衍化生長因子單克隆抗體細胞定位：細胞膜
產(chǎn)品介紹：background: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Subunit: Interacts with the activin type-1 receptor ACVR1B. Subcellular Location: Cell membrane;畸胎瘤衍化生長因子單克隆抗體 Lipid-anchor, GPI-anchor. Tissue Specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Similarity: Contains 1 EGF-like domain. Database links: NCBI Reference Sequence: NP_003203.1 UniProtKB/Swiss-Prot: P13385.1 Important Note: This product as supplied is intended for research use only, not for use in 畸胎瘤衍化生長因子單克隆抗體human, therapeutic or diagnostic applications. Cripto-1是表皮生長因子-Cripto-FRL-Criptic(EGF-CFC)家族成員之一, 屬于轉化生長細胞TGF-β蛋白家族及Nodal蛋白質的共同受體。Cripto蛋白對于胚胎的發(fā)育占有非常重要的地位。 Cripto-1在人類的多種腫瘤如結腸癌、乳腺癌、卵巢癌、胰腺癌等中高表達，可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信號通路,介導細胞增殖和抑制細胞凋亡，Cripto蛋白的單細胞繁殖抗體，可以有效抑制一些癌細胞的生長。
畸胎瘤衍化生長因子單克隆抗體產(chǎn)品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：腫瘤 **學 信號轉導 細胞凋亡 生長因子和** 轉錄調節(jié)因子
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Mouse
外觀： Lyophilized or Liquid
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