人類**狀瘤病毒18 E6單克隆抗體
規(guī)格：1mg/1ml
英文名： HPV18 E6 protein
別名： E6; Human Papilloma Virus; Human papillomavirus type 18 E6; Human papillomavirus type 18 (E6); Human papillomavirus type 18 E6; Human papillomavirus type 18 E6 protein; Protein E6; HPV18 E6 protein; V
分子量： 11kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Monoclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from HPV18 E6 prote
交叉反應：HPV18
人類**狀瘤病毒18 E6單克隆抗體細胞定位：
產品介紹：background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high 人類**狀瘤病毒18 E6單克隆抗體and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Function: Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation. Subunit: Forms a complex with E6-AP ubiquitin-protein ligase which interacts with human P53. Binds to human FBLN1, MAGI3 and MPDZ. Subcellular Location: Host nucleus matrix (By similarity). 人類**狀瘤病毒18 E6單克隆抗體Similarity: Belongs to the papillomaviridae E6 protein family. Gene ID: 1489088 Database links: Entrez Gene: 1489088 HPV18 E6 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人類**狀瘤病毒18（HPV18-E6）是導致女性宮頸癌的主要病毒型（包括人類**狀瘤病毒16）
人類**狀瘤病毒18 E6單克隆抗體產品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：腫瘤 **學 **及病毒
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Mouse
外觀： Lyophilized or Liquid
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