內(nèi)皮素-1單克隆抗體
規(guī)格：1mg/1ml
英文名： ET-1(2C4)
別名： Big endothelin 1; EDN 1; EDN1; EDN1 protein; Endothelin1; ET 1; ET1; OTTHUMP; PPET1; Preproendothelin 1; Preproendothelin1
分子量： 2.5kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Monoclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ET-1(CSC
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
內(nèi)皮素-1單克隆抗體細(xì)胞定位：
產(chǎn)品介紹：background: Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms - ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. Endothelin 1 is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Function: Endothelins are endothelium-derived vasoconstrictor內(nèi)皮素-1單克隆抗體 peptides. Subcellular Location: Secreted. Tissue Specificity: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Similarity: Belongs to the endothelin/sarafotoxin family. Gene ID: 1906 Database links: Entrez Gene: 1906 Human Entrez Gene: 13614 Mouse Entrez Gene: 24323 Rat Omim: 131240 Human SwissProt: P05305 Human SwissProt: P22387 Mouse SwissProt: P22388 Rat Unigene:內(nèi)皮素-1單克隆抗體 511899 Human Unigene: 713645 Human Unigene: 10918 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 內(nèi)皮素(Endothelin-1,ET)是一種強(qiáng)的血管收縮劑，分為ET-1,ET-2,ET-3 三種,ET-1主要在內(nèi)皮細(xì)胞中表達(dá),而ET-2和ET-3則主要在神經(jīng)系統(tǒng)中表達(dá)。ET具有廣泛的生物學(xué)作用，此抗體是針對(duì)內(nèi)皮素的活性片段（CSCSSLMDKECVYFCHLDIIW Disulfide bridges C1-C15, C3-C11）。
內(nèi)皮素-1單克隆抗體產(chǎn)品應(yīng)用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：心血管 神經(jīng)生物學(xué)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Mouse
外觀： Lyophilized or Liquid
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