Background:

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway.

Applications:

WB, IF

Name of antibody:

MAP4K4

Immunogen:

Synthesized peptide derived from internal of human MEKKK 4.

Full name:

mitogen-activated protein kinase kinase kinase kinase 4

Synonyms：

HGK; NIK; MEKKK4; FLH21957; HEL-S-31

SwissProt:

O95819

WB Predicted band size:

142 kDa

WB Positive control:

COLO cells and Huvec cells lysates

WB Recommended dilution:

500-3000

IF positive control:

A549 cells

IF Recommend dilution:

100-500