Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Applications:

WB, IHC

Name of antibody:

MAP2K7(Phospho-Ser271)

Immunogen:

Peptide sequence around phosphorylation site of Serine271(V-D-S(p)-K-A) derived from Human MAP2K7.

Full name:

mitogen-activated protein kinase kinase 7

Synonyms：

MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4

SwissProt:

O14733

IHC positive control:

Humanbrain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

47 kDa

WB Positive control:

NIH/3T3 cells lysates treated with insulin

WB Recommended dilution:

500-1000