Background:

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Applications:

ELISA, IHC

Name of antibody:

PTPN22

Immunogen:

Fusion protein of human PTPN22

Full name:

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Synonyms：

LYP; PEP; LYP1; LYP2; PTPN8

SwissProt:

Q9Y2R2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human ovarian cancer

IHC Recommend dilution:

30-150