鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體
規(guī)格：1mg/1ml
英文名： NKCC1/SLC12A2
別名： Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; mBSC2; NKCC1; S12A2_HUMAN; SLC12A2; sodium-potassium-chloride cotransporter 1; solute carrie
分子量： 133kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NKCC1
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Chimpanzee,
細(xì)胞定位：細(xì)胞膜
鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體產(chǎn)品介紹：background: Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome. Function: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in many tissues. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the SLC12A transporter family. Database links: Entrez Gene: 471620 Chimpanzee Entrez Gene: 286845 Cow Entrez Gene: 481490 Dog Entrez Gene: 6558 Human Entrez Gene: 20496 Mouse Entrez Gene: 100516960 Pig Entrez Gene: 鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體83629 Rat Omim: 600840 Human SwissProt: P55011 Human SwissProt: P55012 Mouse Unigene: 162585 Human Unigene: 712970 Human Unigene: 399997 Mouse Unigene: 11523 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鈉鉀離子轉(zhuǎn)運(yùn)蛋白1抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid
- 溫馨提示：為規(guī)避購(gòu)買風(fēng)險(xiǎn)，建議您在購(gòu)買前務(wù)必確認(rèn)供應(yīng)商資質(zhì)與產(chǎn)品質(zhì)量。
- 免責(zé)申明：以上內(nèi)容為注冊(cè)會(huì)員自行發(fā)布，若信息的真實(shí)性、合法性存在爭(zhēng)議，平臺(tái)將會(huì)監(jiān)督協(xié)助處理，歡迎舉報(bào)